Biloxi city spokesman Vincent Creel says emergency responders were still removing injured people from the bus more than 30 minutes after the crash Tuesday. The incident occurred at 2:12 p.m. local time.
CBS affiliate WLOX-TV reports the bus was stopped on the tracks when it was struck by the eastbound CSX train in Biloxi.
More details to come.
Biloxi's police chief, John Miller, said: "It's a bad tragedy and I know there's a lot of families that are going to be impacted".
The CSX train was traveling east when it hit the bus a few hours ago. Charter buses often carry patrons to casinos in Biloxi, but Creel says he doesn't know where this bus was headed.
"It's a awful, chaotic scene", Miller said.
Miller said it was still unclear to investigators why the bus had come to a stop along the tracks.
A nearby hospital set up a triage unit at the site to treat the injured, and helicopters were carrying the injured to hospitals that handle trauma cases.
Craig Robinson, who witnessed the crash, told the Sun Herald: "My first instinct was to get down there and tell people to get off the bus, but by the time I got there the train had already hit it".
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