Despite Nadal's one-sided record against Isner, it was a hard-fought contest from the outset, and the American showed off his outstanding serving as he fired down 22 aces, per ProTennisLive.
He said: "Happy about the match today".
In the women's draw, former world No. 1 and fourth seed Karolina Pliskova became the latest high-profile casualty, going out in the third round to unseeded Sorana Cirstea. "Maybe I still do have energy to play", she said. Asked if he thought Nadal could win 10 French Open titles throughout his career, Corretja replied: 'No, no, no.
Dimitrov earlier defeated No.5 Roberto Bautista Agut 7-6 (7-5) 4-6 6-2.
The Spaniard, a 16-time Grand Slam champion, saw off Russian Karen Khachanov 6-3, 6-3 to book a last-eight clash with Isner. The two also went fishing at sea. "But we had some good dinner".
Nick Kyrgios smashed a racket after losing the first set, sang a song while relaxing during a changeover, and then advanced to the quarterfinals.
Kyrgios will take on second-seeded Alexander Zverev.
Krygios was leading Belgium's Steve Darcis 6-0, 3-0 when his opponent retired injured.
A blockbuster second-round meeting with wildcard and 2009 US Open champion Juan Martin del Potro followed as the match-up definitely lived up to the hype it received, with Dimitrov prevailing in the high-quality encounter after exactly two hours of play.
The eighth-seeded Australian rallied to beat Mischa Zverev 3-6, 6-2, 6-2, finding some degree of redemption for his ill-tempered, suspension-earning performance against the German a year ago in Shanghai.
Second-ranked Halep moved into the women's semifinal by defeating Daria Kasatkina of Russian Federation 6-2, 6-1.
Halep, 26, could potentially usurp Muguruza at the top if she reaches the final in Beijing. Halep's quarterfinal win avenged her straight-sets loss to the 34th-ranked Kasatkina at Wuhan last week.
"We are pretty good friends from the Fed Cups", she said.
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