A point against the Citizens could secure the Saints' Premier League status for the next season, although, given their superior goal difference, only a huge defeat, coupled with a big win for Swansea could put them in peril.
They have already broken Chelsea's Premier League points record by racking up 97 with a 3-1 win over Brighton, and another win against south coast opposition this weekend would bring up the magic 100.
The Premier League awards £420m prize money across the 20 clubs at the end of the season, with each Premier League place is worth £2m depending on how high a team finishes.
When the most recent top-flight TV deal came into force, there was a major concern that it would only serve to widen the gulf between the Premier League and those in the divisions below.
Gael Clichy revealed the brutal way in which Pep Guardiola told him his playing career is effectively done and dusted upon the Spaniard's arrival at Manchester City.
Mark Hughes is unlikely to make a whole lot of tactical changes going up against his former employers, meaning Southampton are likely to set out in a 3-4-2-1 setup once again. In the Premier League we had 17 games, before we arrived the club played 20.
Even though relegation is now nearly impossible, Southampton will still need to put a good performance in to prevent a bloodbath on the pitch to reduce any remaining chances of dropping down to the Championship and to also see out the season in style. They will then hold an open-top bus parade in Manchester city centre on Monday to celebrate their title and Carabao Cup triumphs.
"They have worked from day one to the last one, training with us, being in the locker room, working".
"Some days I will be here because the kids are in school, some days I'll be in Manchester with (director of football) Txiki (Begiristain) or (chief executive) Ferran (Soriano)".
"But we have mobile phones and I do need to leave Manchester a little bit and have holidays with wife and kids".
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