Guardiola said. "When you win for 100 points it's something special for the club".
Xherdan Shaqiri also missed a penalty for Stoke, whose victory means they finish the season with their first win in 14 Premier League games.
Manchester City trailed for a total of just 153 minutes in Premier League matches this season - the fewest by a side in a single campaign.
Liverpool are 25 points behind City going into this Sunday's final round of fixtures but they have inflicted defeat on Guardiola's team three times this season, ending their unbeaten league record in January before winning both legs of their Champions League quarter final.
"We did it all season, no surrender, try until the end", he said.
The goal was City's 106th of the campaign, breaking the previous record of 103 set by Chelsea in their 2009-10 title-winning campaign.
City have also got the most away wins (16) and points (50) ever collected in a Premier League season.
With a 19-point advantage over United, City outperformed their rivals' 1999-2000 margin of 18 over Arsenal.
However, Gabriel Jesus' late victor at Southampton took City to 32 victories, which means that they now also have the overall record for an English top-flight season - previously held by Tottenham Hotspur, who recorded 31 wins in the old First Division in 1960-61.
The only two spots left for grabs was the final Champions League place between Liverpool and Chelsea and the final relegation place that Southampton and Swansea are trying to avoid.
The financial pressures of building the stadium at a reported £1 billion cost could also hamper Pochettino's progress, although a third consecutive season of Champions League football should ease some of the burden. "I speak to the owners and they ask me to work next season even if we do not know what will happen".
Badou Ndiaye lobbed in the leveller and Peter Crouch scored what proved to be the victor before the break, converting the 1000th Premier League goal of the season, while Xherdan Shaqiri missed a penalty in a drab second half.
Arsenal are set for the biggest change of all as after 22 years in charge, Arsene Wenger has stepped aside as manager.
Needing to beat Stoke, Southampton to lose to Manchester City and a 10-goal swing in goal difference in their favour, Swansea were realistically relegated when Huddersfield guaranteed their survival by holding Chelsea on Wednesday. Chelsea, Arsenal and Burnley will go to the Europa League.
Andy King's goal gave Swansea hope of an unlikely final-day comeback, but Badou Ndiaye and Peter Crouch scored to ensure already relegated Stoke would not end the season bottom.
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