The outstanding Hirving Lozano smashed the victor in the 35th minute at the Luzhniki Stadium, leaving Manuel Neuer clutching at air on his return to the German goal after a 9-month injury absence.
But the day belonged to forward Hirving Lozano, who scored the game's only goal late in the first half, and goalkeeper Guillermo Ochoa, who made that score stand up with a brilliant performance, turning away nine shots to shut Germany out.
But despite nearly constant pressure they were largely kept at long range, and their poor finishing rarely threatened Ochoa as Mexico held out for only their second victory against the Germans in 12 attempts. They hadn't lost an opening game since the then-West Germany succumbed 2-1 to Algeria in 1982.
Check out our brand new daily JOE World Cup Minipod with Dion Fanning and Paddy McKenna with added Mad Vlad Putin, Spanish managerial weeping and probably some football as well.
From there, they had Germany rattled and fully deserved the goal from Hirving Lozano when it came.
The 2014 champions begin their title defense on Sunday morning as Germany enter the 2018 World Cup as heavy favorites to move deep in the tournament once again.
But despite the loss - the first for a German team in a World Cup opener since 1982 - coach Joachim Low remains confident that his side will progress to the knockout stage in Russian Federation.
Germany coach Joachim Loew had taken a "B" side to the tournament, which was considered a dress rehearsal for the World Cup, and that show in Sochi was a validation of the world champions' strength in depth.
"In the first half we played very badly", Low said. As we saw with Argentina on Saturday, all it takes is one match in which the favourites look a bit shaky and the rest can start to smell blood. The Germans were also visibly slower when faced with frequent runs from Hernandez and Lozano, finding themselves backtracking all too often, and not being able to put bodies behind and in front of Neuer in goal. This should be an intriguing battle between two teams buoyed by Germany's loss to Mexico in Group F. Fubo TV also offers three days of auto recording and 30 hours of Cloud DVR service in case you're busy at work for the Germany Mexico soccer game.
Seeking defensive reinforcement, Mexico coach Juan Carlos Osorio brought on 39-year-old veteran Rafael Marquez to play in his fifth World Cup. After all, when Germany pulled off a huge upset at the Winter Olympics by defeating Canada 4-3 in the men's ice hockey semi-finals, the Germans couldn't resist a bit of gloating.
- At Least 4 Feared Dead in Texas Border Crash
- Roger Federer wins Mercedes Cup with victory over Milos Raonic
- 23-foot-long python swallows woman whole
- Paul Manafort Is Going to Jail
- DoJ Report Biased, Reached Wrong Conclusion
- Trump 'could issue pardons after Russian Federation probe', lawyer Rudy Giuliani claims
- Gal Gadot reveals first clear look at Wonder Woman in '1984' sequel
- 'Earthquake of Joy' in Mexico over World Cup upset win
- 5 people die in South Texas pursuit crash involving undocumented immigrants
- Bouhaddouz own goal hands Iran late victory over Morocco