The 57-year-old was travelling to the set of his new TV show Catch 22 in Costa Corallina when a vehicle turned and struck him.
According to local Italian media reports, the actor, who is in Sardinia to film a miniseries was travelling along a state road in Costa Corallina when the accident occurred.
According to the site, George was said to be hit by a auto which suddenly changed direction at a spot close to a hotel.
The famous actor was taken to an emergency room in nearby Olbia, however, his injuries are said not to be serious.
In pictures from the crash, obtained by the MailOnline, the auto involved in the crash appears to have a smashed windscreen, suggesting George may even have hit it during the crash.
They claim that he injured his pelvis in the smash, but after being x-rayed was sent home. He has been in Sardinia since mid May, shooting TV series Catch 22, which he is directing and in which he also stars, alongside Hugh Laurie, Kyle Chandler and Christopher Abbott.
Clooney, 57, had just left his hotel on a motor scooter when he crashed into a small truck, Italy's Chi magazine said on its website.
Calls and emails to Clooney's spokesman in regards to the accident weren't immediately returned, according to Associated Press. According to CNN, the Oscar victor was thrown over the top of his scooter after being hit by a Mercedes while in Olbia on the island of Sardinia.
Sardinia is a large Italian island in the Mediterranean Sea and is over 500 miles from Clooney's villa in Lake Como.
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