The diagnosis ends his rookie season nearly immediately after it had begun.
Guice was injured in Washington's preseason opener at New England on Thursday night and could be seen on the sideline with ice on his knee.
The Redskins said Guice, who was taken in the second round of the National Football League draft out of LSU, was expected to make a full recovery and was looking forward to playing in 2019.
Several scouts had questioned Guice's durability going into the draft. He played sparingly a year ago, and likely won't see his role increase that much as a result of Guice's injury. His season is officially over before it really got started. Coach Jay Gruden has said there was competition for the No. 1 job along with third-down back Chris Thompson.
Guice ran with bad intentions in his career with the Tigers, averaging north of 4.0 yards after contact per attempt in each of his first two seasons with the team (2015-16).
The former LSU star was fourth on the Redskins' depth chart at running back, but was expected to have a significant role this season.
In Weeks 11-17, Perine averaged 2.65 yards after contact per attempt, ranking 12th among running backs with at least 100 attempts in said span.
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