All but 39 of the confirmed cases are in children.
Residents living in the Williamsburg zip codes of 11205, 11206, 11211, and 11249 must be vaccinated against measles, mumps, and rubella or they face the possibility of fines that can reach up to $1000.
The city said it would help everyone covered by the order get the vaccine if they can't get it quickly through their regular medical provider.
"If people will simply co-operate quickly, nobody will have to pay a fine", de Blasio said.
More than 280 people in Brooklyn and Queens have come down with measles since September. The Centers for Disease Control and Prevention (CDC) "strongly recommends against hosting or participating in these events".
The order is signed to remain in effect until the next meeting of the New York City Board of Health on April 17 at which time "it may be continued or rescinded by the board".
"We will make sure that everybody who is allowed will be vaccinated", Rabbi David Niederman, the president of the United Jewish Organizations of Williamsburg, said in a phone interview.
Barbot cited a group of "anti-vaxxers" who are seeking to undermine the public health emergency. "They have been spreading risky misinformation based on fake science", Barbot said.
"We have a situation now where children are in danger".
"We can not ignore the number of people becoming sick from the Measles in NY", said State Sen.
"When people choose not to get their children vaccinated, they are putting their children and others - such as pregnant women, people on chemotherapy, and the elderly - at risk of contracting measles", Herminia Palacio, NYC's deputy mayor for health and human services, said in the release.
The vaccine is 97 percent effective, according to Health Commissioner Dr. Oxiris Barbot, and if someone is exposed to the disease, he or she has a three-day window to still get vaccinated and limit the damage.
"Look it's a serious public health concern, but it's also a serious First Amendment issue and it is going to be a constitutional, legal question", Cuomo said.
Officials say 285 measles cases have been confirmed in New York City since the beginning of the outbreak, the largest in the city since 1991.
Government pushes for inoculations and public space bans of unvaccinated children have prompted a backlash among anti-vaccination activists, whose misinformation campaigns have led to declines for vaccinations against one of the world's most contagious diseases. "The measles vaccine works".
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